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Obesity Clinic

Drugs used in the treatment of Obesity

For a free private consultation on weight loss please call the clinic on 01525 40 30 40

Obesity Clinic

Obesity is associated with many health problems including cardiovascular (Heart) disease, diabetes mellitus, gallstones and osteoarthritis. Factors that aggravate Obesity may include depression, other psychological problems, and some drugs.

The main treatment of the Obese individual is a suitable diet, carefully explained to the individual, with appropriate support and encouragement:

  • The individual should also be encouraged to increase physical activity.
  • Smoking cessation (while maintaining body weight) may be worthwhile before attempting supervised weight loss as cigarette smoking may be more harmful than obesity.
  • Attendance at some groups (e.g. weight-watchers) helps some individuals.

Severe Obesity should be managed in an appropriate setting by staffs that have been trained in the management of obesity; the individual should receive advice on diet and lifestyle modification and be monitored for changes in weight as well as in blood pressure, blood lipids and other associated conditions.

An anti obesity drug should be considered only for those with a body mass index of 30Kg/M2 or greater in whom at least 3 months of managed care involving supervised diet, exercise and behaviour modification fails to achieve a realistic reduction in weight.

In the presence of risk factors it may be appropriate to prescribe a drug to individuals with a BMI of 27 KG/M2 or greater provided that such use is permitted by the drugs marketing authorisation.

Drugs should never be used as the sole element of treatment, the individual should be monitored on a regular basis; drug treatment should be discontinued if the individual regains weight at any time whilst receiving drug treatment.

Drugs specifically licensed for the management of Obesity are:

  1. Orlistat,
  2. Sibutramine
  3. Rimonabant.

There is little evidence to guide selection between these drugs but it may be appropriate to choose Orlistat for those who have a high intake of fats, where as Sibutramine or Rimonabant may be chosen for those who cannot control their eating.

Combination therapy involving more than one anti obesity drug is contra indicated until further information about efficacy and long term safety is available.

Thyroid hormones have no place in the treatment of Obesity except in biochemically proven Hypo thyroid patients. The use of diuretics, chronic gonadotrophin or amphetamines is not appropriate for weight reduction.

For a consultation on weight loss please call the clinic on 01525 40 30 40

How does Acomplia (Rimonabant) work?

Acomplia represents a novel way of controlling body weight. It operates by being a cannabinoid receptor antagonist.

The active ingredient in Acomplia is rimonabant. It works by blocking specific receptors in the brain and the fat tissues called 'CB1' receptors. This means that Acomplia (rimonabant) prevents the normal action of the natural levels of cannabinoid in the brain from stimulating these CB1 receptors. It is believed that these receptors stimulate appetite and therefore when they are blocked, the desire to eat and so consumption of food is reduced. Put simply Acomplia (rimonobant) suppresses appetite signals from the brain and fatty tissue that promotes eating.

Acomplia comes as a tear drop shaped, white film coated tablet with '20' punched into one side. It is an oral tablet which is swallowed.

Does Acomplia (Rimonabant) always work?

Clinical trials have been conducted in over 6800 people in total. They were either obese or overweight with hypertension and or dyslipidaemia. 80% were women, 87% were Caucasian and 9% were Black. They followed a diet and were advised to exercise more.

Over 1 year an average weight loss of 6.5kg was seen for those who took Acomplia compared to an average weight loss of 1.6kg for those who took a 'placebo'.

Around 50% of the group lost 5% of their body weight and 27% lost 10%

Similar results were seen in a group of type 2 diabetics.

Most of the weight loss occurred in the first 9 months of treatment and the weight stayed off for 2 years and in fact Acomplia (rimonabant) reduced the risk of weight regain.

Effects were the same for men and women, but weight loss seemed to be less for Black patients.

Acomplia (Rimonabant) side effects

Like all medicines Acomplia (rimonabant) can cause side effects, although not everybody gets them.

Common side effects that affect more than 10% of patients include nausea and upper respiratory tract infection. Other less common side effects include upset stomach, vomiting, sleeping disorders, nervousness and depression, dizziness, diarrhoea, itching, excessive sweating, muscle cramps, fatigue, bruising, tendonitis, back pain, memory loss, hot flush, influenza and joint sprain. Rarely it can cause hallucinations, lethargy, panic attacks, hiccups, anger and restlessness.

Is Acomplia (Rimonabant) for everyone?

Acomplia (Rimonabant) should only be taken if your doctor has prescribed it for you.

Acomplia (Rimonabant) is not recommended for use in children below the age of 18 due to the lack of data in this population.

Acomplia should not be taken by women who are pregnant or breast feeding their baby.

'Acomplia' should not be used with caution with certain other medicines (ketoconazole, itraconazole, ritonavir, telithromycin, clarithromycin, nafazadone) and you should tell your doctor about all other medicines you are taking when he prescribes Acomplia.

How do I get Acomplia (Rimonabant)?

You need a prescription from your doctor to legally obtain Acomplia (Rimonabant). Companies offering Acomplia without a valid prescription are breaking the law, and you may be putting your health at risk. Or attend a clinic at the Retreat 01525 40 30 40.

Highly convenient and embarrassment free and supply of Acomplia (Rimonabant)

For many people who are prescribed treatments for weight loss (obesity) , taking their prescription to the pharmacy represents an embarrassing hurdle which some may not overcome. At the Retreat we offer private discreet clinics, and you can also obtain your prescription from us.

Reductil (Sibutramine) and weight loss (obesity)

When can Reductil (Sibutramine) be prescribed to help weight loss (obesity)?

Reductil is licensed as adjunctive therapy within a weight management programme aimed to promote weight loss. It is a prescription only medicine which can be prescribed for obese patients with a body mass index (BMI) of greater than 30 kg/m 2 or for overweight patients with a body mass index (BMI) of greater than 27 kg/m 2 who also have other risk factors such as type 2 diabetes or dyslipidaemia (a disturbance in the levels of fat (lipids) in the blood).

Reductil may only be prescribed to patients who have tried to lose weight by diet and exercise for 3 months or more and have been unsuccessful in losing at least 5% of their body weight. It can only be used under the ongoing care of a doctor experienced in the treatment of obesity.

For information on this treatment please attend a clinic at the Retreat 01525 40 30 40.

How many people are over weight or obese?

People are classed as obese if they have a body mass index over 30. They are overweight if it is 25-30. Please contact us to help assess your BMI.

Adult obesity rates have almost quadrupled in the last 25 years. Now over 20% of Britons are obese and three-quarters are classed as overweight.

What are the causes of obesity?

In most otherwise healthy people, the causes of being obese or overweight are simple: eating too many calories or taking too little exercise, or more than likely a combination of both!

The plethora of fad diets have convinced many people that eating low fat or low carbohydrate foods can provide a short cut to losing weight.

Your body has the capability to convert fat to carbohydrates and carbohydrates to fat depending on the quantity of each it has available to it, so manipulating the amount taken in the diet in an attempt to lose weight is largely useless. In otherwise healthy people, it is equally untrue that some people have a 'slow metabolism' and so are more likely to put on weight.

The simple fact is that if you regularly consume more calories than you burn off, you will put on weight. The good news is that if you burn off more calories than you consume on a regular basis you WILL lose weight. The only guaranteed way to lose weight is therefore to eat less, do more and preferably do both.

Why does weight loss (obesity) matter?

Despite being a very common condition being obese or overweight can have serious effects. Obesity can lead to extremely serious health problems, including arthritis, heart disease and diabetes. Because of this, in England , over 30,000 deaths a year are caused by obesity. It has been estimated that obesity costs the NHS £500 million a year. The overall cost to the country is thought to be over £7 billion every year.

Treatment of obesity or the promotion of weight loss with Reductil (Sibutramine)

As discussed above the best way to guarantee weight loss is to consume fewer calories and take more exercise. In addition to these doctors can prescribe Reductil, which has been shown to assist in weight loss.

How does Reductil (Sibutramine) work?

Reductil operates by its active metabolites inhibiting the reuptake of noradrenalin serotonin and to a lesser extent dopamine.

This action enhances 'satiety' or the feeling of being full, and this reduces food intake. In addition Reductil also has a 'thermogenic' effect by which it increases the level of calories burnt while at rest, during a weight loss programme.

Reductil comes as hard capsules which are swallowed.

Reductil (Sibutramine) side effects

Like all medicines Reductil (sibutramine) can cause side effects, although not everybody gets them

Common side effects that affect more than 10% of patients include loss of appetite, constipation, dry mouth and sleeping problems. Other less common side effects include fast heartbeats, palpitations, abnormal heart rhythm, high blood pressure, hot flushes, sweating, odd sense of taste, light headedness, pins and needles, headaches and feeling anxious. Rarely it can cause kidney and liver problems, purple leg rash and bruising, seizures, blurred vision, depression, suicidal thoughts, restlessness, hair loss, short term memory loss, impotence and menstrual disorders.

Is Reductil (Sibutramine) for everyone?

Reductil (Sibutramine) should only be taken if your doctor has prescribed it for you.

Reductil (Sibutramine) is not for use in children below the age of 18 due to the lack of data in this population.

Reductil (Sibutramine) is not for use in people over the age of 65 due to the lack of data in this population.

Reductil should not be taken by women who are pregnant or breast feeding their baby.

Reductil should not be taken by people with a history of common problems including heart disease or uncontrolled high blood pressure, hyperthyroidism, severe liver or kidney problems, benign prostatic hyperplasia and certain types of glaucoma.

'Reductil' should not be used with caution with certain other medicines (monoamine oxidase inhibitors or other antidepressants or antipsychotic, other weight reduction medicines or tryptophan for sleep disturbances) and you should tell your doctor about all other medicines you are taking when he prescribes Reductil.

How do I get Reductil (Sibutramine)?

You need a prescription from your doctor to legally obtain Reductil (Sibutramine). Companies offering Reductil without a valid prescription are breaking the law, and you may be putting your health at risk. Or visit a clinic at the Retreat 01525 40 30 40

Xenical (Orlistat) and weight loss (obesity)

When can Xenical (Orlistat) be prescribed to help weight loss (obesity)?

Xenical is indicated in conjunction with a reduced calorie diet to treat obesity. Xenical is a prescription only medicine which can be prescribed for obese patients with a body mass index (BMI) of greater than 30 kg/m2 or for overweight patients with a body mass index (BMI) of greater than 28 kg/m2 who also have other risk factors.

Xenical should be stopped if a patient has not lost 5% of their body weight in the first 12 weeks of use.

How many people are over weight or obese and so could use Xenical?

People are classed as obese and can have a prescription for Xenical if they have a body mass index over 30. They are overweight if it is 25-30. Please contact us to assess your BMI – 01525 40 30 40.

Adult obesity rates have almost quadrupled in the last 25 years. Now over 20% of Britons are obese and three-quarters are classed as overweight.

What are the causes of obesity?

In most otherwise healthy people, the causes of being obese or overweight are simple: eating too many calories or taking too little exercise, or more than likely a combination of both!

The plethora of fad diets have convinced many people that eating low fat or low carbohydrate foods can provide a short cut to losing weight. Your body has the capability to convert fat to carbohydrates and carbohydrates to fat depending on the quantity of each it has available to it, so manipulating the amount taken in the diet in an attempt to lose weight is largely useless. In otherwise healthy people, it is equally untrue that some people have a 'slow metabolism' and so are more likely to put on weight.

The simple fact is that if you regularly consume more calories than you burn off, you will put on weight. The good news is that if you burn off more calories than you consume on a regular basis you WILL lose weight. The only guaranteed way to lose weight is therefore to eat less, do more and preferably do both. Xenical can help by helping you consume fewer calories.

Why does weight loss (obesity) matter?

Despite being a very common condition being obese or overweight can have serious effects. Obesity can lead to extremely serious health problems, including arthritis, heart disease and diabetes. Xenical can help avoid these problems. Because of these serious health problems, in England, over 30,000 deaths a year are caused by obesity. It has been estimated that obesity costs the NHS £500 million a year. The overall cost to the country is thought to be over £7 billion every year.

Treatment of obesity or the promotion of weight loss with Xenical (Orlistat)

As discussed above the best way to guarantee weight loss is to consume fewer calories and take more exercise. In addition to these doctors can now prescribe Xenical, which has been shown to assist in weight loss.

How does Xenical (Orlistat) work?

Xenical reduces the body’s ability to absorb dietary fat into the body by inhibiting gastric and pancreatic lipases in the stomach and small intestine. This stops the body from being able to change the fat into a form in which it can be taken into the body – and so count as calories!

Does Xenical (Orlistat) always work?

In clinical trials about 6 out of 10 patients taking xenical in conjunction with a reduced calorie diet lost 5% of their body weight after 12 weeks. If 5% of the body weight was not lost in the first 12 weeks then continual treatment was largely ineffective. Of those patients that did lose 5% or more of their body weight in the first 12 weeks, 62% of these lost 10% of their body weight in 1 year. In addition the weight loss delayed the development of type 2 diabetes during the study.

Xenical (Orlistat) side effects

Like all medicines Xenical (orlistat) can cause side effects. The most common is the desperate need to defecate, flatulence with discharge, oily anal discharge and oily or fatty poo. Abdominal pain and discomfort is also very common as are headaches and infections such as flu chest infections and urinary tract infections. Rarely an allergic reaction can occur. If you feel unwell when taking xenical you should tell your doctor immediately.

Is Xenical (Orlistat) for everyone?

Xenical should only be taken if prescribed by a doctor. Xenical should not be taken by people suffering with chronic malabsorption syndrome, cholestasis or by breast-feeding women. The use of an additional contraceptive method is recommended to prevent possible failure of oral contraception that could occur because of the severe diarrhoea that can occur with Xenical. Xenical can also interact with other medication so it is important to tell your doctor about all medication you are taking when he prescribes xenical.

How do I get Xenical (Orlistat)?

You need a prescription from your doctor to legally obtain Xenical (orlistat). Companies offering Xenical without a valid prescription are breaking the law, and you may be putting your health at risk. Low cost, highly convenient and embarrassment free and supply of Xenical (Orlistat) is available via the Retreat on 01525 40 30 40. For many people who are prescribed treatments for weight loss (obesity), taking their prescription to the pharmacy represents an embarrassing hurdle which some may not overcome. In addition, some pharmacies will charge a great deal more than others to dispense your Xenical prescription.

If your unhappy with your weight, you are not alone. Please make a start and arrange to visit a private obesity clinic at the Retreat.

For Appointments call 01525 40 30 40




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